Coelho lab

We use gene editing technologies at scale to investigate the function of DNA variants in cancer genomes.

DNA mutations accumulate over time in cancer cells. Our lab finds out how these mutations affect cancer progression and response to therapy.

An analogy is the DNA cycle path in Cambridge, where, over time, each DNA base has become eroded leading to mistakes in the code – these are DNA mutations. How they affect gene function can be determined by installing these experimentally into cancer cells.

In our lab, we use state-of-the art genome editing technologies such as base editing and prime editing and link them to high-content readouts such as single-cell RNA sequencing.

Funding

We are grateful to the following charities and organisations for funding our research